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CD8 alpha Rabbit Polyclonal Antibody

CAT: 0992-ER2001-19Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-19Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
CAS Number
9007-83-4
Product Name Alternative
CD8 antibody CD8 antigen, alpha polypeptide (p32) antibody CD8a antibody CD8a antigen antibody CD8a molecule antibody CD8A_HUMAN antibody Leu2 antibody Leu2 T lymphocyte antigen antibody MAL antibody OKT8 T cell antigen antibody p32 antibody T cell antigen Leu2 antibody T cell co receptor antibody T-cell surface glycoprotein CD8 alpha chain antibody T-lymphocyte differentiation antigen T8/Leu-2 antibody T8 T cell antigen antibody
Abbreviation
T-cell surface glycoprotein CD8 alpha chain T-lymphocyte differentiation antigen T8/Leu-2 CD8a
Swiss Prot
P01732 Human
Cellular Locus
Cell membrane, Membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human CD8A aa 1-235.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Siha cell lysates, MCF-7, human spleen tissue, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 26 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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