hnRNP Q Recombinant Rabbit Monoclonal Antibody [JG35-72]

hnRNP Q Recombinant Rabbit Monoclonal Antibody [JG35-72]

• Description: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.
• Product Name Alternative: cytoplasmic RNA-interacting protein antibody dJ3J17.2 antibody Glycine and tyrosine rich RNA binding protein antibody Glycine- and tyrosine-rich RNA-binding protein antibody GRY RBP antibody GRY-RBP antibody GRYRBP antibody Heterogeneous nuclear ribonucleoprotein Q antibody hnRNP Q antibody HNRPQ antibody HNRPQ_HUMAN antibody HNRPQ1 antibody NS1 associated protein 1 antibody NS1-associated protein 1 antibody NSAP1 antibody pp68 antibody RP1 3J17.2 antibody Synaptotagmin binding cytoplasmic RNA interacting protein antibody Synaptotagmin-binding antibody Syncrip antibody
• Abbreviation: hnRNP Q, GRY-RBP, SYNCRIP, HNRPQ, NSAP1
• CAS Number: 9000-83-3
• Swiss Prot: O60506 Human, Q7TP47 Rat, Q7TMK9 Mouse
• Cellular Locus: Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthetic peptide within Human hnRNP Q aa 574-623 / 623.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, IF-Tissue
• Positive Control: K562 cell lysates, rat brain tissue lysates, LOVO, SiHa, rat testis tissue, human thyroid tissue, human breast tissue, human kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 70 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes