hnRNP U Recombinant Rabbit Monoclonal Antibody [JB23-43]

hnRNP U Recombinant Rabbit Monoclonal Antibody [JB23-43]

• Description: Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.
• Product Name Alternative: Heterogeneous nuclear ribonucleoprotein U antibody hnRNP U antibody hnRNP U protein antibody HNRNPU antibody hnRNPU protein antibody HNRPU antibody HNRPU_HUMAN antibody p120 antibody p120 nuclear protein antibody pp120 antibody SAF A antibody SAF-A antibody SAFA antibody Scaffold attachment factor A antibody U21.1 antibody
• Abbreviation: hnRNP U, SAF-A, HNRNPU, C1orf199, HNRPU, SAFA, U21.1
• CAS Number: 9000-83-3
• Swiss Prot: Q00839 Human, Q8VEK3 Mouse, Q6IMY8 Rat
• Cellular Locus: Nucleus. Cytoskeleton.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinantpeptide within Human hnRNP U aa 1-140 / 825.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: NIH/3T3 cell lysate, SH-SY5Y cell lysate, K562 cell lysate, A431, HepG2, SH-SY5Y, rat brain tissue, human tonsil tissue, human lung carcinoma tissue, human kidney tissue, mouse colon tissue, human cervix tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human esophagus tissue, human placenta tissue, mouse bladder tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000;IF-Cell: 1:100-1:500;IHC-P: 1:50-1:400
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 91 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes