hnRNP C1+C2 Recombinant Rabbit Monoclonal Antibody [SN0652]

hnRNP C1+C2 Recombinant Rabbit Monoclonal Antibody [SN0652]

• Description: Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport, and also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. hnRNP complexes are the major constituents of the spliceosome and, in particular, the hnRNP A1 protein is one of the major pre-mRNA/mRNA binding proteins and also one of the most abundant proteins in the nucleus. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The majority of hnRNP proteins components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. Most hnRNP proteins, in-cluding hnRNP C1 and C2, contain one or more RNA binding domains and are implicated in the processing of pre-mRNA. hnRNPs F and H are largely related factors that preferentially associate with poly (rG) regions on RNA. Isoforms of these proteins are often generated by alternative processing of the pre-mRNA and by posttranslational modifications such as phosphorylation on serines and threonines and methylation of arginines.
• Product Name Alternative: C1 antibody C2 antibody Heterogeneous nuclear ribonucleoprotein C (C1/C2) antibody Heterogeneous nuclear ribonucleoprotein C antibody Heterogeneous nuclear ribonucleoproteins C1/C2 antibody HNRNP antibody hnRNP C1 / hnRNP C2 antibody hnRNP C1/C2 antibody Hnrnpc antibody HNRPC antibody HNRPC_HUMAN antibody MGC104306 antibody MGC105117 antibody MGC117353 antibody MGC131677 antibody Nuclear ribonucleoprotein particle C1 protein antibody Nuclear ribonucleoprotein particle C2 protein antibody SNRPC antibody
• Abbreviation: hnRNP C1/C2, HNRNPC
• CAS Number: 9000-83-3
• Swiss Prot: P07910 Human, Q9Z204 Mouse, P17132 Rat
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Recombinant protein of Human HNRNPC aa 60-190 / 306.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: Hela cell lysate, HepG2 cell lysate, MCF-7 cell lysate, Hela, MCF-7, B16F1, human breast carcinoma tissue, human kidney tissue, mouse brain tissue, mouse skin tissue, mouse placenta tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 34 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes