IKK gamma Recombinant Rabbit Monoclonal Antibody [JA11-83]

IKK gamma Recombinant Rabbit Monoclonal Antibody [JA11-83]

• Description: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
• Product Name Alternative: IkB kinase associated protein 1 antibody IkB kinase subunit gamma antibody Inhibitor of nuclear factor kappa B kinase subunit gamma antibody AMCBX1 antibody FIP 3 antibody FIP-3 antibody FIP3 antibody Fip3p antibody I kappa B kinase gamma antibody I-kappa-B kinase subunit gamma antibody IkB kinase gamma subunit antibody IkB kinase subunit gamma antibody IkB kinase-associated protein 1 antibody Ikbkg antibody IKK-gamma antibody IKKAP1 antibody IKKG antibody IMD33 antibody Incontinentia pigmenti antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma antibody Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody IP antibody IP1 antibody IP2 antibody IPD2 antibody NEMO antibody NEMO_HUMAN antibody NF kappa B essential modifier antibody NF kappa B essential modulator antibody NF-kappa-B essential modifier antibody NF-kappa-B essential modulator antibody ZC2HC9 antibody
• Abbreviation: NEMO, IKKAP1, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, IKBKG, FIP3, NEMO
• CAS Number: 9000-83-3
• Swiss Prot: Q9Y6K9 Human, O88522 Mouse, Q6TMG5 Rat
• Cellular Locus: Nucleus. Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human IKK gamma aa 1-286 / 419.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, IF-Tissue, IP, FC
• Positive Control: Hela cell lysates, Hela, human spleen tissue, human colon carcinoma tissue, mouse colon tissue, mouse fallopian tissue, human colon tissue, human placenta tissue, mouse heart tissue,Hela, rat cerebellum tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:400;FC: 1:50-1:100;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes