PP1C gamma Rabbit Polyclonal Antibody

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

9007-83-4

PP 1G antibody PP-1G antibody PP1C antibody PP1G antibody PP1G_HUMAN antibody PP1gamma antibody PPP 1G antibody PPP1CC antibody PPP1G antibody Protein phosphatase 1, catalytic subunit, gamma isozyme antibody Protein phosphatase 1C catalytic subunit antibody Serine/threonine phosphatase 1 gamma antibody Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody

PPP1CC

P36873 Human, P63087 Mouse, P63088 Rat

Nucleus, Mitochondrion, Cytoplasm, Kinetochore, Cleavage furrow, Midbody.

Synthetic peptide within human PP1C gamma aa 293-323.

Non-conjugated

Rabbit polyclonal Antibody

WB, IHC-P

293 cell lysate, mouse lung tissue lysate, rat brain tissue lysate, human prostate tissue, human stomach tissue.

1 mg/mL

WB: 1:2,000-1:5,000 ;IHC-P: 1:100-1:500

Immunogen affinity purified.

Liquid

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

37 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.