Thioredoxin Recombinant Rabbit Monoclonal Antibody [JM10-019]

Thioredoxin Recombinant Rabbit Monoclonal Antibody [JM10-019]

• Description: Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.
• Product Name Alternative: ADF antibody ATL derived factor antibody ATL-derived factor antibody DKFZp686B1993 antibody MGC61975 antibody SASP antibody Surface associated sulphydryl protein antibody Surface-associated sulphydryl protein antibody testicular tissue protein Li 199 antibody THIO_HUMAN antibody Thioredoxin antibody thioredoxin delta 3 antibody TRDX antibody TRX 1 antibody Trx antibody TRX1 antibody TXN antibody TXN delta 3 antibody TXN protein antibody zgc:92903 antibody
• Abbreviation: Trx, ADF, SASP, TXN
• CAS Number: 9000-83-3
• Swiss Prot: P10599 Human
• Cellular Locus: Nucleus, Cytoplasm, Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Thioredoxin aa 6-50 / 105.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P
• Positive Control: Hela cell lysates, Hela, MCF-7, SKOV-3, human fallopian tube tissue, human uterus tissue, human small intestine tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100-1:200 ;IF-Tissue: 1:100-1:200 ;IHC-P: 1:400
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 12 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes