pro Caspase-7 Recombinant Rabbit Monoclonal Antibody [SD20-57]

pro Caspase-7 Recombinant Rabbit Monoclonal Antibody [SD20-57]

• Description: A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly (ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
• Product Name Alternative: Caspase7 apoptosis-related cysteine peptidase antibody Apoptotic protease Mch-3 antibody CASP-7 antibody CASP7 antibody CASP7_HUMAN antibody Caspase-7 subunit p11 antibody Caspase-7 antibody Caspase 7 antibody Caspase7 antibody CMH-1 antibody ICE-LAP3 antibody ICE-like apoptotic protease 3 antibody
• Abbreviation: CASP-7, ICE-LAP3, CASP7
• CAS Number: 9000-83-3
• Swiss Prot: P55210 Human
• Cellular Locus: Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Caspase 7 aa 1-50 / 303.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P
• Positive Control: Hela, HepG2, human liver tissue, human kidney tissue,human lung lysates.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 34 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes