Caspase-7 Recombinant Rabbit Monoclonal Antibody [JE59-36]

Caspase-7 Recombinant Rabbit Monoclonal Antibody [JE59-36]

• Description: Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
• Product Name Alternative: Apoptotic protease Mch-3 antibody Apoptotic protease MCH3 antibody CASP-7 antibody CASP7 antibody CASP7_HUMAN antibody Caspase 7 antibody Caspase 7 apoptosis related cysteine peptidase antibody Caspase-7 subunit p11 antibody Caspase7 antibody CMH 1 antibody CMH-1 antibody CMH1 antibody ICE LAP3 antibody ICE-LAP3 antibody ICE-like apoptotic protease 3 antibody LICE2 antibody MCH3 antibody
• Abbreviation: Casp7, Lice2, Mch3
• CAS Number: 9000-83-3
• Swiss Prot: P97864 Mouse,
• Cellular Locus: Cytoplasm, cytosol, Nucleus, Secreted, extracellular space.
• Host: Rabbit
• Species Reactivity: Mouse, Rat
• Immunogen: Recombinant protein within Mouse Caspase-7 aa 204-303 / 303.
• Isotype: IgG
• Clone: JE59-36
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Tissue
• Positive Control: RAW264.7 cell lysate, C2C12 cell lysate, C6 cell lysate, PC-12 cell lysate, mouse colon tissue, rat colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000 ;IF-Tissue: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 34 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes