Products for Research Use Only
RegisterLogin

Caspase-1 Rabbit Polyclonal Antibody

CAT: 0992-R1510-23Size: 100 µLDry Ice: NoHazardous: No
Product image 1Product image 2Product image 3
1 / 3
CAT#:0992-R1510-23Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.
CAS Number
9007-83-4
Product Name Alternative
Caspase1 CASP-1 antibody CASP1 antibody CASP1_HUMAN antibody Caspase1 antibody Caspase 1 antibody Caspase-1 subunit p10 antibody ICE antibody IL-1 beta-converting enzyme antibody IL-1BC antibody IL1 beta converting enzyme antibody IL1B convertase antibody Interleukin 1 beta convertase antibody Interleukin 1B converting enzyme antibody Interleukin-1 beta convertase antibody Interleukin-1 beta-converting enzyme antibody p45 antibody
Abbreviation
CASP-1,IL-1BC,ICE,IL-1 beta-converting enzyme
Swiss Prot
P29466 Human
Cellular Locus
Cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human Caspase-1 aa 162-205.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell, IHC-P, FC
Positive Control
HepG2, human lung tissue, human liver tissue, Jurkat.
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
46 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

Related Products

CatalogName
ER30804Caspase-3 Rabbit Polyclonal Antibody
HA500144Caspase-12 Rabbit Polyclonal Antibody
HA750161Caspase-1 Recombinant Rabbit monoclonal Antibody
R1308-12Active+Pro Caspase-9 Rabbit Polyclonal Antibody
ET1608-69Caspase-1 Recombinant Rabbit Monoclonal Antibody [SU40-07]
ET1608-69-50ULCaspase-1 Recombinant Rabbit monoclonal Antibody [SU40-07]
ET1608-69TRAnti-Caspase-1 Antibody [SU40-07]
HA750971Caspase-8 Recombinant Rabbit monoclonal Antibody
HA750062Caspase-9 Recombinant Rabbit monoclonal Antibody
HA751482Caspase-7 Recombinant Rabbit monoclonal Antibody

Alternative Products

CatalogName
APRab03841-01Caspase 1 Rabbit Polyclonal Antibody
NB100-56564Rabbit Polyclonal Caspase-1 Antibody
E53P04472Caspase-1 Rabbit Polyclonal Antibody
GTR17763681-01Caspase-1 p20 Rabbit Polyclonal Antibody
APRab03387-01Cleaved-Caspase 1 Rabbit Polyclonal Antibody
NBP1-76605BRabbit Polyclonal Caspase-1 Antibody [Biotin]
AP06610PU-NCaspase 1 (CASP1) Rabbit Polyclonal Antibody

Popular Products