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Caspase-12 Rabbit Polyclonal Antibody

CAT: 0992-HA500144Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500144Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase-5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.
CAS Number
9007-83-4
Product Name Alternative
Caspase12 CASP 12 antibody CASP-12 antibody Casp12 antibody CASP12P1 antibody caspase 12 (gene/pseudogene) antibody caspase 12 pseudogene 1 antibody CASPC_HUMAN antibody Inactive caspase-12 antibody OTTHUMP00000207032 antibody
Abbreviation
CASP12
Swiss Prot
Q6UXS9 Human, O08736 Mouse, Q920D5 Rat
Cellular Locus
Cytosol, endoplasmic reticulum, cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human Caspase-12 aa 170-341.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Rat liver tissue lysate, Mouse liver tissue lysate, human liver tissue, human heart tissue, mouse heart tissue, rat heart tissue, human pancreas tissue, rat kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:200-1:400
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 39 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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