Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890]

Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890]

• Description: Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.
• Product Name Alternative: Caspase10 ALPS2 antibody Apoptotic protease Mch-4 antibody CASP 10 antibody CASP-10 antibody CASP10 antibody CASPA_HUMAN antibody Caspase 10 apoptosis related cysteine peptidase antibody Caspase-10 subunit p12 antibody FADD like ICE2 antibody Fas associated death domain protein antibody FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody FLICE 2 antibody FLICE2 antibody ICE like apoptotic protease 4 antibody ICE-like apoptotic protease 4 antibody Interleukin 1B converting enzyme 2 antibody MCH 4 antibody
• Abbreviation: CASP-10, FLICE2, CASP10
• CAS Number: 9000-83-3
• Swiss Prot: Q92851 Human
• Cellular Locus: Cytosol.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human Caspase-10 aa 254-452 / 521.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC, IP
• Positive Control: K562 cell lysates, human liver carcinoma tissue, human kidney tissue, K562.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;FC: 1:50-1:100 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 59 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes