TNFAIP3 Recombinant Rabbit Monoclonal Antibody [SN07-31]

TNFAIP3 Recombinant Rabbit Monoclonal Antibody [SN07-31]

• Description: A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IκB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
• Product Name Alternative: A20 antibody AISBL antibody MGC104522 antibody MGC138687 antibody MGC138688 antibody OTU domain containing protein 7C antibody OTU domain-containing protein 7C antibody OTUD7C antibody Putative DNA binding protein A20 antibody Putative DNA-binding protein A20 antibody TNAP3_HUMAN antibody TNF alpha-induced protein 3 antibody TNFA1P2 antibody TNFAIP 3 antibody TNFAIP3 (A20) antibody TNFAIP3 antibody Tumor necrosis factor alpha induced protein 3 antibody Tumor necrosis factor alpha-induced protein 3 antibody Tumor necrosis factor induced protein 3 antibody Tumor necrosis factor inducible protein A20 antibody tumor necrosis factor, alpha-induced protein 3 antibody Zinc finger protein A20 antibody
• Abbreviation: TNF alpha-induced protein 3, TNFAIP3
• CAS Number: 9000-83-3
• Swiss Prot: P21580 Human
• Cellular Locus: Cytoplasm, Nucleus, Lysosome.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human TNFAIP3 aa 491-540 / 790.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, FC
• Positive Control: Jurkat cell lysates, Hela, A549, HepG2, human kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 90 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes