TNFAIP3 Rabbit Polyclonal Antibody

TNFAIP3 Rabbit Polyclonal Antibody

• Description: A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
• Product Name Alternative: A20 antibody AISBL antibody MGC104522 antibody MGC138687 antibody MGC138688 antibody OTU domain containing protein 7C antibody OTU domain-containing protein 7C antibody OTUD7C antibody Putative DNA binding protein A20 antibody Putative DNA-binding protein A20 antibody TNAP3_HUMAN antibody TNF alpha-induced protein 3 antibody TNFA1P2 antibody TNFAIP 3 antibody TNFAIP3 (A20) antibody TNFAIP3 antibody Tumor necrosis factor alpha induced protein 3 antibody Tumor necrosis factor alpha-induced protein 3 antibody Tumor necrosis factor induced protein 3 antibody Tumor necrosis factor inducible protein A20 antibody tumor necrosis factor, alpha-induced protein 3 antibody Zinc finger protein A20 antibody
• Abbreviation: TNF alpha-induced protein 3, TNFAIP3, OTUD7C
• CAS Number: 9007-83-4
• Swiss Prot: P21580 Human, Q60769 Mouse, M0R7V5 Rat
• Cellular Locus: Cytoplasm, Nucleus, Lysosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human TNFAIP3 aa 225-410 / 790.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Jurkat, Daudi, A431, LOVO, rat lung tissue, human liver cancer tissue, human kidney tissue, mouse testis tissue, HepG2.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 90 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No