VASP Recombinant Rabbit Monoclonal Antibody [SY02-16]

VASP Recombinant Rabbit Monoclonal Antibody [SY02-16]

• Description: The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity, and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. WASP has been identified as a downstream effector of Cdc42 and has been implicated in Actin polymer-ization and cytoskeletal organization. A distantly related protein, VASP (vaso-dilator-stimulated phosphoprotein), is involved in the maintenance of cytoarchitecture by interacting with Actin-like filaments. VASP shares a limited degree of homology with the amino-terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP de-pendent kinases, VASP is phosphorylated on a regulatory Serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is highly expressed in human platelets and, like WASP, may play a role in cytoskeletal organization.
• Product Name Alternative: Vasodilator stimulated phosphoprotein antibody Vasodilator-stimulated phosphoprotein antibody VASP antibody VASP_HUMAN antibody
• Abbreviation: VASP
• CAS Number: 9000-83-3
• Swiss Prot: P50552 Human
• Cellular Locus: Cytoplasm, Cell junction, Cell projection.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human VASP aa 51-100 / 380.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IP
• Positive Control: HT29, MCF-7, Hela.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 46 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes