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CDk1 Rabbit Polyclonal Antibody

CAT: 0992-ER31213Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER31213Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cdk1 is a small protein (approximately 34 kilodaltons), and is highly conserved. Cdk1 is comprised mostly by the bare protein kinase motif, which other protein kinases share. Cdk1, like other kinases, contains a cleft in which ATP fits. When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression. Given its essential role in cell cycle progression, Cdk1 is highly regulated. Most obviously, Cdk1 is regulated by its binding with its cyclin partners. Cyclin binding alters access to the active site of Cdk1, allowing for Cdk1 activity; furthermore, cyclins impart specificity to Cdk1 activity. At least some cyclins contain a hydrophobic patch which may directly interact with substrates, conferring target specificity. Furthermore, cyclins can target Cdk1 to particular subcellular locations.
CAS Number
9007-83-4
Product Name Alternative
Cdc 2 antibody Cdc2 antibody CDC28A antibody CDK 1 antibody CDK1 antibody CDK1_HUMAN antibody CDKN1 antibody CELL CYCLE CONTROLLER CDC2 antibody Cell division control protein 2 antibody Cell division control protein 2 homolog antibody Cell division cycle 2 G1 to S and G2 to M antibody Cell division protein kinase 1 antibody Cell Divsion Cycle 2 Protein antibody Cyclin Dependent Kinase 1 antibody Cyclin-dependent kinase 1 antibody DKFZp686L20222 antibody MGC111195 antibody p34 Cdk1 antibody p34 protein kinase antibody P34CDC2 antibody
Abbreviation
CDK1
Swiss Prot
P06493 Human
Cellular Locus
Cytoplasm, nucleus, Cytoskeleton, Mitochondrion.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within N-terminal human CDk1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
MCF-7 cell lysate, Jurkat cell lysate, PC12 cell lysate, HepG2 cell lysate, Hela cell lysate, NIH/3T3 cell lysate, mouse liver tissue lysate, SKBR3 cell lysate, HeLa, NIH/3T3, rat spleen tissue, human tonsil tissue, human breast cancer tissue, mouse spleen tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IF-Cell: 1:100 ;IHC-P: 1:200 ;FC: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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