Stat-1 alpha/beta Rabbit Polyclonal Antibody

• Description:

  STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.

• Product Name Alternative:

  CANDF7 antibody DKFZp686B04100 antibody ISGF 3 antibody ISGF3 antibody OTTHUMP00000163552 antibody OTTHUMP00000165046 antibody OTTHUMP00000165047 antibody OTTHUMP00000205845 antibody Signal transducer and activator of transcription 1 antibody Signal transducer and activator of transcription 1, 91kDa antibody Signal transducer and activator of transcription 1-alpha/beta antibody Stat1 antibody STAT1_HUMAN antibody STAT91 antibody Transcription factor ISGF-3 components p91/p84 antibody

• Abbreviation:

  Stat-1

• CAS Number:

  9007-83-4

• Swiss Prot:

  P42224 Human

• Cellular Locus:

  Cytoplasm, nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide within human Stat-1 alpha/beta 76-119

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, FC

• Positive Control:

  MCF-7 cell lysate, Hela cell lysate, NIH/3T3 cell lysate, HepG2, MCF-7, Hela, human breast cancer tissue, human kidney tissue, mouse kidney tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:200 ;FC: 1:100-1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 87 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No