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alpha 1 Spectrin Rabbit Polyclonal Antibody

CAT: 0992-HA500357Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500357Size:100 µL
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Description
Spectrin alpha chain, erythrocyte is a protein that in humans is encoded by the SPTA1 gene. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
CAS Number
9007-83-4
Product Name Alternative
Alpha I spectrin antibody EL 2 antibody EL2 antibody Elliptocytosis 2 antibody Elliptocytosis2 antibody Erythrocyte alpha spectrin antibody erythrocyte antibody Erythroid alpha spectrin antibody Erythroid alpha-spectrin antibody Erythroid spectrin alpha antibody HPP antibody HS3 antibody Spectrin alpha chain antibody Spectrin alpha chain erythrocyte antibody Spectrin alpha erythrocytic 1 antibody SPH3 antibody SPTA 1 antibody SPTA antibody SPTA1 antibody SPTA1_HUMAN antibody
Abbreviation
SPTA1
Swiss Prot
P02549 Human, P08032 Mouse
Cellular Locus
Cytoplasm, Cytoskeleton.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within Human alpha 1 Spectrin aa 1-200 / 2,419.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
K562 cell lysate, NIH/3T3 cell lysate, A549 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 280 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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