P2X7 Rabbit Polyclonal Antibody
CAT:
992-ER1901-99
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
P2X7 Rabbit Polyclonal Antibody
- Description: P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria.The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina. The P2X7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death,regulation of receptor trafficking, mast cell degranulation, and inflammation. Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells
- Product Name Alternative: ATP receptor antibody P2rx7 antibody P2RX7_HUMAN antibody P2X purinoceptor 7 antibody P2X7 antibody P2Z receptor antibody Purinergic receptor antibody purinergic receptor P2X, ligand gated ion channel, 7 antibody
- Abbreviation: P2X purinoceptor 7,P2X7,ATP receptor,P2Z receptor,Purinergic receptor,P2rx7
- CAS Number: 9007-83-4
- Swiss Prot: Q99572 Human, Q9Z1M0 Mouse, Q64663 Rat
- Cellular Locus: Cell membrane.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide corresponding to C terminal Rat P2X7.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P, FC
- Positive Control: SH-SY5Y cell lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, rat brain tissue lysate, rat brain tissue, human kidney tissue, mouse brain tissue, THP-1.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:2000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 69 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No