SB 235375

CAT: 0804-HY-117380-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-117380-01Size:5 mg
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Description
SB 235375 is a potent and selective antagonist of the human neurokinin-3 (hNK-3) receptor designed by optimizing the structure of 2-phenyl-4-quinolinecarboxylic acid amide. SB 235375 displays high affinity for the hNK-3 receptor, with significantly higher binding affinities than hNK-2 and hNK-1 receptors. In vitro studies demonstrated its ability to block NK-3 receptor-mediated contraction and calcium mobilization, while in vivo, SB 223412 demonstrated oral and intravenous activity against NK-3 receptor-driven responses in animal models[1].
CAS Number
[224961-34-6]
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-235375.html
Purity
98.13
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N[C@H](C1=CC=CC=C1)CC)C2=C(C(C3=CC=CC=C3)=NC4=CC=CC=C24)OCC(O)=O
Molecular Formula
C27H24N2O4
Molecular Weight
440.49
References & Citations
[1]Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S) -N- (1-phenylpropyl) -3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412) . J Med Chem. 1999 Mar 25;42 (6) :1053-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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