ACCN2 Rabbit Polyclonal Antibody

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.Isoform 1 does not display proton-gated cation channel activity.

9007-83-4

ACCN2 antibody ACCN2_HUMAN antibody Acid sensing ion channel 1 antibody Acid sensing ion channel 1a protein antibody Acid sensing ion channel antibody Acid-sensing ion channel 1 antibody AI843610 antibody Amiloride sensitive cation channel 2 neuronal antibody Amiloride-sensitive cation channel 2 antibody ASIC antibody ASIC1 antibody ASIC1A antibody B530003N02Rik antibody BNaC2 antibody Brain sodium channel 2 antibody Cation channel amiloride sensitive neuronal 2 antibody hBNaC2 antibody neuronal antibody

ASIC1, BNaC2, ASIC1, ACCN2, BNAC2

P78348 Human, Q6NXK8 Mouse, P55926 Rat

Cell membrane.

Synthetic peptide within Human ACCN2 aa 457-506 / 528.

Non-conjugated

Rabbit polyclonal Antibody

WB, IHC-P, FC

SH-SY-5Y, rat brain tissue, mouse brain tissue.

1 mg/mL

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 60 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.