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macroH2A.1 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-04Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-04Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin.
CAS Number
9007-83-4
Product Name Alternative
Core histone macro h2a.1 antibody Core histone macro-H2A.1 antibody H2A histone family member Y antibody H2A.y antibody H2A/y antibody H2AF12M antibody H2AFJ antibody H2afy antibody H2AY_HUMAN antibody Histone H2A.Y antibody Histone macroH2A1 antibody Histone macroH2A1.1 antibody Histone macroH2A1.2 antibody Macroh2a1 antibody MACROH2A1.1 antibody MacroH2A1.2 antibody Medulloblastoma antigen MU MB 50.205 antibody Medulloblastoma antigen MU-MB-50.205 antibody mH2a antibody mH2A1 antibody
Abbreviation
Histone macroH2A1, mH2A1, H2A/y, H2AFY, MACROH2A1
Swiss Prot
O75367 Human, Q9QZQ8 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within human macroH2A.1 aa 190-369.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
HeLa cell lysate, MCF7 cell lysate, NIH/3T3 cell lysate, MDA-MB-231 cell lysate, human colon tissue, human placenta tissue, mouse brain tissue, SiHa.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 40 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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