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Beclin 1 Rabbit Polyclonal Antibody

CAT: 0992-R1510-8Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1510-8Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BECN1 (Beclin 1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. BECN1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the Ribosomal Protein S6, and both are mediated via amino acids. BECN1 expression in various carcinoma cell lines such as MCF7 is low, whereas it is ubiquitously expressed in normal breast tissue. In transfected MCF7 cells, BECN1 complements autophagocytosis and, subsequently, inhibits cellular proliferation. Additionally, BECN1 shares structural similarity to the yeast autophagy gene product, Apg6, and was one of the first mammalian proteins discovered to mediate autophagy.
CAS Number
9007-83-4
Product Name Alternative
APG6 antibody ATG 6 antibody ATG6 antibody ATG6 autophagy related 6 homolog antibody Bcl-2-interacting protein beclin antibody Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody Beclin 1 autophagy related antibody Beclin-1 antibody Beclin1 antibody BECN 1 antibody Becn1 antibody BECN1_HUMAN antibody Coiled coil myosin like BCL2 interacting protein antibody Coiled-coil myosin-like BCL2-interacting protein antibody GT197 antibody Protein GT197 antibody VPS 30 antibody VPS30 antibody
Abbreviation
BECN1
Swiss Prot
Q14457 Human, O88597 Mouse
Cellular Locus
Cytoplasm, Endosome, Mitochondrion membrane Mitochondrion membrane, Endoplasmic reticulum membrane
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within N-terminal human BECN1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell, IHC-P, FC
Positive Control
Hela, N2A, MCF-7, SHG-44, human liver cancer tissue, human breast tissue, human lung tissue, human kidney tissue, mouse brain tissue, mouse heart tissue, HepG2.
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
52 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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