ATF6 Rabbit Polyclonal Antibody
CAT:
992-ER1706-34
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ATF6 Rabbit Polyclonal Antibody
- Description: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
- Product Name Alternative: Activating transcription factor 6 alpha antibody Activating transcription factor 6 antibody ATF 6 antibody ATF6 alpha antibody ATF6 antibody ATF6-alpha antibody ATF6A antibody ATF6A_HUMAN antibody cAMP dependent transcription factor ATF 6 alpha antibody cAMP-dependent transcription factor ATF-6 alpha antibody Cyclic AMP dependent transcription factor ATF 6 alpha antibody DKFZp686P2194 antibody ESTM49 antibody FLJ21663 antibody Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody
- Abbreviation: Trx, ADF, SASP, TXN, TRDX, TRX, TRX1
- CAS Number: 9007-83-4
- Swiss Prot: P18850 Human
- Cellular Locus: Endoplasmic reticulum membrane. Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.
- Host: Rabbit
- Species Reactivity: Human, Rat
- Immunogen: Recombinant protein within Human ATF6 aa 168-392 / 670.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: Hela, A431, HUVEC, K562, rat brain tissue, human kidney tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
- Purity: Protein A affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: 75 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No