ATF6 Recombinant Mouse Monoclonal Antibody [8D3-R]

ATF6 Recombinant Mouse Monoclonal Antibody [8D3-R]

• Description: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
• Product Name Alternative: Activating transcription factor 6 alpha antibody Activating transcription factor 6 antibody ATF 6 antibody ATF6 alpha antibody ATF6 antibody ATF6-alpha antibody ATF6A antibody ATF6A_HUMAN antibody cAMP dependent transcription factor ATF 6 alpha antibody cAMP-dependent transcription factor ATF-6 alpha antibody Cyclic AMP dependent transcription factor ATF 6 alpha antibody DKFZp686P2194 antibody ESTM49 antibody FLJ21663 antibody Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody
• Abbreviation: cAMP-dependent transcription factor ATF-6 alpha, ATF6-alpha, ATF6
• CAS Number: 9000-83-3
• Swiss Prot: P18850 Human, F6VAN0 Mouse, G3V909 Rat
• Cellular Locus: Endoplasmic reticulum. Nucleus.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human ATF6 aa 1-670 / 670.
• Isotype: IgG1
• Clone: 8D3-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: HeLa cell lysate, Jurkat cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, mouse brain tissue lysate, mouse kidney tissue lysate, HeLa.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 75 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes