GRP94 Rabbit Polyclonal Antibody

Heat shock protein (HSP) molecular chaperones are environmental stress-inducible gene products. The human HSP 90 family includes 17 genes that fall into four classes: HSP90AA, HSP90AB, HSP90B and TRAP. HSP 90 family members guide the normal folding, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. HSP 90α, also designated HSP90A, HSP 86 and LPS-associated protein 2 (LAP2), is a cytosolic enhancer of inducible nitric-oxide synthase (iNOS), with chaperone activity that is important for the transcriptional activity of p53. HSP 90β, also designated HSP90B, HSP 84 and HSPC2, is a cytosolic protein that participates in signaling pathways with PKC e to protect cells from external damage, particularly in heat shock-mediated events. GRP 94, also known as tumor rejection antigen 1 (TRA1), ECGP and GP96, localizes to the ER, is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1. TRAP1 (TNF receptor-associated protein 1), also designated HSP 75) is a mitochondrial matrix component that plays a role in the induction of apoptosis in response to reactive oxygen species.

9007-83-4

94 kDa glucose regulated protein antibody 94 kDa glucose-regulated protein antibody ECGP antibody Endoplasmin antibody Endothelial cell (HBMEC) glycoprotein antibody ENPL_HUMAN antibody Glucose regulated protein 94kDa antibody gp96 antibody gp96 homolog antibody GRP 94 antibody GRP-94 antibody Heat shock protein 90 kDa beta member 1 antibody heat shock protein 90kDa beta (Grp94), member 1 antibody Heat shock protein, 90 kDa, beta, 1 antibody HSP90B1 antibody Stress inducible tumor rejection antigen GP96 antibody TRA1 antibody tumor rejection antigen (gp96) 1 antibody Tumor rejection antigen 1 antibody Tumor rejection antigen gp96 antibody Tumor rejection antigen-1 (gp96) antibody

GRP-94, HSP90B1, GRP94, TRA1

P14625 Human, P08113 Mouse, Q66HD0 Rat

Endoplasmic reticulum lumen, Melanosome.

Synthetic peptide within human GRP94 aa 194-247.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P

HepG2 cell lysate, HeLa cell lysate, human brain tissue lysate, NIH/3T3 cell lysate, mouse placenta tissue lysate, mouse brain tissue lysate, PC-12 cell lysate, rat placenta tissue lysate, rat brain tissue lysate, Hela, HepG2, MCF-7, human liver tissue, human breast tissue, human stomach cancer tissue, mouse stomach tissue.

1 mg/mL

WB: 1:500-1:2,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:100-1:500

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 92 kDa

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.