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NOX2/gp91phox Rabbit Polyclonal Antibody

CAT: 0992-ER1511-34Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1511-34Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutro-phils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.
CAS Number
9007-83-4
Product Name Alternative
AMCBX2 antibody CGD antibody CGD91-phox antibody CY24B_HUMAN antibody CYBB antibody Cytochrome b 245, beta polypeptide antibody Cytochrome b (558) beta chain antibody Cytochrome b (558) subunit beta antibody Cytochrome b-245 heavy chain antibody Cytochrome b558 subunit beta antibody GP91 PHOX antibody gp91-1 antibody gp91-phox antibody GP91PHOX antibody Heme-binding membrane glycoprotein gp91phox antibody NADPH oxidase 2 antibody Neutrophil cytochrome b 91 kDa polypeptide antibody NOX2 antibody p22 phagocyte B-cytochrome antibody P91 PHOX antibody p91-PHOX antibody Superoxide-generating NADPH oxidase heavy chain subunit antibody
Abbreviation
Cytochrome b558 subunit beta, CYBB, NOX2
Swiss Prot
P04839 Human, Q61093 Mouse
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide corresponding to C-terminal human NOX2/gp91phox.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell, IHC-P, FC
Positive Control
HepG2, MCF-7, Hela, human liver tissue, human spleen tissue, human tonsil tissue, mouse spleen tissue.
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:500-1:1,000;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 65 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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