Netrin receptor DCC Rabbit Polyclonal Antibody

• Description:

  Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.

• Product Name Alternative:

  Colorectal cancer related chromosome sequence 18 antibody Colorectal cancer suppressor antibody CRC 18 antibody CRC18 antibody CRCR 1 antibody CRCR1 antibody DCC antibody DCC_HUMAN antibody Deleted in colorectal cancer protein antibody Deleted in colorectal carcinoma antibody Immunoglobulin superfamily DCC subclass member 1 antibody Netrin receptor DCC antibody Tumor suppressor protein DCC antibody

• Abbreviation:

  DCC

• Swiss Prot:

  P43146 Human

• Cellular Locus:

  Cell membrane

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein with of Human Netrin receptor DCC aa 21-299 / 1447.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IF-Cell, IHC-P, FC

• Positive Control:

  Human brain, mouse brain

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 90 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4