Rapamycin-d3

• Description :

  Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant[1][2].

• Product Name Alternative :

  Sirolimus-d3; AY-22989-d3; NSC 226080-d3

• UNSPSC :

  12352005

• Hazard Statement :

  H225, H302+H312+H332, H319

• Target :

  Autophagy; FKBP; Isotope-Labeled Compounds; mTOR

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Others; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Purity :

  95.92

• Solubility :

  DMSO : 110 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@]1(O[C@@H](CC[C@H]1C)C[C@@H](/C(C)=C/C=C/C=C/[C@H](C2)C)OC([2H])([2H])[2H])O)C(N3[C@@H](CCCC3)C(O[C@@H](CC([C@@H](/C=C([C@H]([C@H](C([C@@H]2C)=O)OC)O)\C)C)=O)[C@@H](C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)=O)=O

• Molecular Formula :

  C51H76D3NO13

• Molecular Weight :

  917.19

• Precautions :

  H225, H302+H312+H332, H319

• References & Citations :

  [1]Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282 (18), 13395-13401.|[2]Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30 (34) :11388-97.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  FKBP12

• CAS Number :

  [392711-19-2]