Products for Research Use Only
RegisterLogin

Rapamycin (GMP Like)

CAT: 0804-HY-10219GL-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10219GL-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rapamycin (Sirolimus) GMP Like is Rapamycin produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
CAS Number
53123-88-9
Product Name Alternative
Sirolimus (GMP Like) ; AY-22989 (GMP Like) ; NSC 226080 (GMP Like)
UNSPSC
12352005
Target
Antibiotic; Autophagy; Bacterial; Endogenous Metabolite; FKBP; Fungal; mTOR
Type
GMP Small Molecules
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rapamycin-gmp-like.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O
Molecular Formula
C51H79NO13
Molecular Weight
914.17
References & Citations
[1]Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282 (18), 13395-13401.|[2]Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30 (34) :11388-97.|[3]Niu H, et al. Rapamycin potentiates cytotoxicity by RP-56976 possibly through downregulation of Survivin in lung cancer cells. J Exp Clin Cancer Res. 2011 Mar 10;30:28.|[4]Zhang JW, et al. Metformin synergizes with rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo. Oncol Lett. 2018 Feb;15 (2) :1811-1816.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, protect from light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Related Products

CatalogName
HY-10219G-01Rapamycin (GMP)
HY-W011053GLNeotame (GMP Like)
HY-B0150GLNicotinamide (GMP Like)
HY-112005GL-01DOPE (GMP Like)
HY-W040193GL-01DSPC (GMP Like)
HY-B0342GLMeglumine (GMP Like)
HY-N0614GLSucralose (GMP Like)
HY-N0322GL-01Cholesterol (GMP Like)
HY-10181GLDasatinib (GMP Like)
HY-B0445GL-01NAD+ (GMP Like)

Alternative Products

CatalogName
HEGFP-0906Recombinant Human Insulin-like Growth factor-1 GMP
P1445-.1Recombinant Human Neuregulin 1-beta2 EGF-like domain GMP
586926-01Insulin-like Growth Factor-1, Active, Recombinant, Human, aa49-118 (IGF1) (GMP)
030984GBL (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8)
035938GBL, CT (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8)
MBS6301448-01GBL, CT (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8) (FITC)
MBS6301447-01GBL, CT (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8) (Biotin)
168531SUMO (Small Ubiquitin-like Modifier, GAP modifying protein 1, GMP 1, PIC 1, Sentrin, Small ubiquitin related modifier 1)
MBS6301455-01GBL, CT (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8) (PE)
MBS6301445-01GBL, CT (MLST8, GBL, LST8, Target of rapamycin complex subunit LST8, G protein beta subunit-like, Mammalian lethal with SEC13 protein 8) (AP)

Popular Products