Aβ/tau aggregation-IN-1

• CAS Number:

  2252162-81-3

• UNSPSC Description:

  Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier[1].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/aβ-tau-aggregation-in-1.html

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC1=C2C(CC/C(C2=O)=C\C3=CC=CC4=C3C=CC=C4)=[N+](C5=CC=CC=C51)C.[I-]

• Molecular Weight:

  492.35

• References & Citations:

  [1] Lv P, et al. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorg Med Chem. 2018;26(16):4693-4705.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported