Setmelanotide (TFA)

Setmelanotide (TFA)

• UNSPSC Description: Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].
• Target Antigen: Melanocortin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/setmelanotide-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CSSC[C@](C(N[C@@H]1C)=O)([H])NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O
• Molecular Weight: 1231.33
• References & Citations: [1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900.
• Shipping Conditions: Room temperature
• Clinical Information: Launched