Setmelanotide (TFA)

• Description:

  Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].

• Product Name Alternative:

  RM-493 (TFA) ; BIM-22493 (TFA) ; IRC-022493 (TFA)

• UNSPSC:

  12352209

• Target:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/setmelanotide-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](CSSC[C@](C(N[C@@H]1C)=O)([H])NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O

• Molecular Formula:

  C51H69F3N18O11S2

• Molecular Weight:

  1231.33

• References & Citations:

  [1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30 (10) :1892-900.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  Launched