Setmelanotide (monoacetate)

Setmelanotide (monoacetate)

• CAS Number: 2759937-80-7
• UNSPSC Description: Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively[1][2].
• Target Antigen: Melanocortin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Endocrinology; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/setmelanotide-monoacetate.html
• Smiles: CC(O)=O.O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)C)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45
• Molecular Weight: 1177.36
• References & Citations: [1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900.|[2]Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported