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Setmelanotide (monoacetate)

CAT: 0804-HY-19870C-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19870C-01Size:1 mg
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Description
Setmelanotide (monoacetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively[1][2].
CAS Number
2759937-80-7
Product Name Alternative
RM-493 (monoacetate) ; BIM-22493 (monoacetate) ; IRC-022493 (monoacetate)
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/setmelanotide-monoacetate.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)=O.O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)C)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45
Molecular Formula
C51H72N18O11S2
Molecular Weight
1177.36
References & Citations
[1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30 (10) :1892-900.|[2]Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62 (2) :490-7.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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