Setmelanotide

• Description :

  Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].

• CAS Number :

  [920014-72-8]

• Product Name Alternative :

  RM-493; BIM-22493; IRC-022493

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Melanocortin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Setmelanotide.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  H2O : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=C(N[C@@H](CSSC[C@](C(N[C@@H]1C)=O)([H])NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45

• Molecular Formula :

  C49H68N18O9S2

• Molecular Weight :

  1117.31

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30 (10) :1892-900.|[2]Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62 (2) :490-7.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  Launched