BIIB 513

• UNSPSC Description:

  BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load[1].

• Target Antigen:

  Na+/H+ Exchanger (NHE)

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/biib-513.html

• Smiles:

  O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CO3)=O)CC2)C(S(=O)(C)=O)=C1.CS(=O)(O)=O

• Molecular Weight:

  515.56

• References & Citations:

  [1]Gumina, et al. "Inhibition of the Na+/H+ exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs." Circulation 100.25 (1999): 2519-2526.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  265986-98-9