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BPI-9016M

CAT: 0804-HY-114356-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114356-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma[1][2].
CAS Number
1528546-94-2
Product Name Alternative
Trimethoprim 3-N-oxide
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bpi-9016m.html
Purity
97.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC=C(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NCC5)=NC=C4)C(F)=C3
Molecular Formula
C25H18F2N4O3
Molecular Weight
460.43
References & Citations
[1]Zhang P, et al. BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1. Theranostics. 2018 Nov 12;8 (21) :5890-5902.|[2]Hu X, et al. First-in-human phase I study of BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer.J Hematol Oncol. 2020 Jan 16;13 (1) :6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

CID 72700713
CAS Number1528546-94-2
PubChem CID72700713
IUPAC NameN-[4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
Molecular FormulaC25H18F2N4O3
Molecular Weight460.4
XLogP3.8
Topological Polar Surface Area92.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity842
SMILES
C1CNC2=NC=CC(=C21)OC3=C(C=C(C=C3)NC(=O)C4=CNC=C(C4=O)C5=CC=C(C=C5)F)F
InChI
InChI=1S/C25H18F2N4O3/c26-15-3-1-14(2-4-15)18-12-28-13-19(23(18)32)25(33)31-16-5-6-22(20(27)11-16)34-21-8-10-30-24-17(21)7-9-29-24/h1-6,8,10-13H,7,9H2,(H,28,32)(H,29,30)(H,31,33)
InChIKey
DGMFNZXEGKFREH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 72700713
CAS: 1528546-94-2
CID: 72700713
Formula: C25H18F2N4O3
MW: 460.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight460.4
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass460.13469677
Monoisotopic Mass460.13469677
Topological Polar Surface Area92.4 Ų
Heavy Atom Count34
Formal Charge0
Complexity842
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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