BPI-15086

• Description :

  BPI-15086 an orally active, potent, irreversible mutant-selective inhibitor of both EGFR and T790M resistance mutations tyrosine kinase. BPI-15086 can be used for the research of non-small-cell lung cancer[1].

• CAS Number :

  [1644502-33-9]

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bpi-15086.html

• Smiles :

  ClC(C(NC1=CC=CC=C1C(C(N(C)C)=O)=O)=N2)=CN=C2NC3=CC(NC(C=C)=O)=C(N4CCN(C)CC4)C=C3OC

• Molecular Formula :

  C29H33ClN8O4

• Molecular Weight :

  593.08

• References & Citations :

  [1]Wang S, et al. Determination of BPI15086 and its metabolite in human plasma by ultra-high performance liquid chromatography-MS/MS and its application to a pharmacokinetic study. Bioanalysis. 2019 Apr;11 (8) :773-784.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1