(-) -Epicatechin gallate

• Description:

  (-) -Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1][2]. (-) -Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-) -Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells[3].

• Product Name Alternative:

  Epicatechin gallate; ECG; (-) -Epicatechin 3-O-gallate

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; COX; GLUT; Virus Protease

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/_-_-Epicatechin-gallate.html

• Purity:

  99.61

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4

• Molecular Formula:

  C22H18O10

• Molecular Weight:

  442.37

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Takizawa Y, et al. Pharmacokinetics of (-) -epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26 (5) :608-12.|[3]Tripp J, et al. Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7 (1) :6197.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 4

• Isoform:

  COX-1; GLUT1

• CAS Number:

  1257-08-5