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(-) -Epicatechin gallate

CAT: 0804-HY-N0002-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0002-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1][2]. (-) -Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-) -Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells[3].
CAS Number
1257-08-5
Product Name Alternative
Epicatechin gallate; ECG; (-) -Epicatechin 3-O-gallate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; COX; GLUT; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/_-_-Epicatechin-gallate.html
Purity
99.61
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4
Molecular Formula
C22H18O10
Molecular Weight
442.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Takizawa Y, et al. Pharmacokinetics of (-) -epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26 (5) :608-12.|[3]Tripp J, et al. Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7 (1) :6197.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
COX-1; GLUT1

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