(-) -Epicatechin gallate

• Description :

  (-) -Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1][2]. (-) -Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-) -Epicatechin gallate decreases cell growth of GLUT5-expressing hxt0 yeast cells[3].

• Product Name Alternative :

  Epicatechin gallate; ECG; (-) -Epicatechin 3-O-gallate

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; COX; GLUT; Virus Protease

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/_-_-Epicatechin-gallate.html

• Purity :

  99.61

• Solubility :

  DMSO : ≥ 30 mg/mL

• Smiles :

  O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4

• Molecular Formula :

  C22H18O10

• Molecular Weight :

  442.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Takizawa Y, et al. Pharmacokinetics of (-) -epicatechin-3-O-gallate, an active component of Onpi-to, in rats. Biol Pharm Bull. 2003 May;26 (5) :608-12.|[3]Tripp J, et al. Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7 (1) :6197.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 4

• Isoform :

  COX-1; GLUT1

• CAS Number :

  [1257-08-5]