(-) -Epicatechin-13C3

• Description:

  (-) -Epicatechin-13C3 ((-) -Epicatechol-13C3) is 13C labeled (-) -Epicatechin. (-) -Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-) -Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

• Product Name Alternative:

  (-) -Epicatechol-13C3; Epicatechin-13C3; epi-Catechin-13C3

• UNSPSC:

  12352005

• Target:

  COX; Endogenous Metabolite; Ferroptosis; Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  OC1=[13C]2[13CH2][C@@H](O)[C@@H](C3=CC=C(O)C(O)=C3)O[13C]2=CC(O)=C1

• Molecular Formula:

  C12 13C3H14O6

• Molecular Weight:

  293.25

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[3]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[4]Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt 18) :4615-31.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported