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(-) -Epicatechin

CAT: 0804-HY-N0001-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0001-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-) -Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
CAS Number
490-46-0
Product Name Alternative
(-) -Epicatechol; Epicatechin; epi-Catechin
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
COX; Endogenous Metabolite; Ferroptosis
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/_-_-Epicatechin.html
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1
Molecular Formula
C15H14O6
Molecular Weight
290.27
Precautions
H315, H319, H335
References & Citations
[1]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40 (2) :173-9.|[2]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[3]Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589 (Pt 18) :4615-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
COX-1

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