PAT-505
CAT:
804-HY-107781-04
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PAT-505
- CAS Number: 1782070-22-7
- UNSPSC Description: PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.
- Target Antigen: Phosphodiesterase (PDE)
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/PAT-505.html
- Purity: 99.47
- Solubility: DMSO : 48.33 mg/mL (ultrasonic)
- Smiles: O=C(O)C1=CC=CC(SC2=C(C3CC3)N(C4=CN(CC)N=C4)C5=C2C=CC(Cl)=C5F)=C1F
- Molecular Weight: 473.92
- References & Citations: [1]Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported