2-PAT

• Description :

  2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC50 of 0.721 μM. 2-PAT is an inactivator of MAO-B with an IC50 of 14.6 μM. 2-PAT has the potential for Parkinson’s disease and depression research[1]. 2-PAT is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  Monoamine Oxidase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-pat.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C#CCNC1CC2=C(C=CC=C2)CC1

• Molecular Formula :

  C13H15N

• Molecular Weight :

  185.26

• References & Citations :

  [1]Letitia Meiring, et al. The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett. 2022 Jul 1;67:128746.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAO-A; MAO-B

• CAS Number :

  [134467-58-6]