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DTAGV-1 (TFA)

CAT: 0804-HY-145514-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145514-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DTAGV-1 TFA is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand ; Black: Linker (HY-W012001) ; Blue: VHL Ligand (HY-112078) ; VHL Ligan+Linker (HY-173628A) )
CAS Number
2624313-15-9
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dtagv-1-tfa.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C(F)(F)F)=O.O=C([C@H]1N(CCCC1)C([C@H](C2=CC(OC)=C(C(OC)=C2)OC)CC)=O)O[C@@H](C3=C(C=CC=C3)OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)CCC7=CC(OC)=C(C=C7)OC
Molecular Formula
C70H91F3N6O16S
Molecular Weight
1361.56
Precautions
H302, H312, H332
References & Citations
[1]Nabet B, et, al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11 (1) :4687.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Citation 01
BioRxiv. 2025 July 08.|bioRxiv. 2025 March 03.|Mayo Clinic. 2025.|Sci Adv. 2025 Nov 28;11 (48) :eadz2345.|Nature. 2025 Feb;638 (8052) :1095-1103.

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