DETD-35

CAT: 0804-HY-164473Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164473Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057) . The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy[1].
CAS Number
[1836209-98-3]
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/detd-35.html
Smiles
O=C(O[C@H]1[C@H](C(C(O2)=O)=C)[C@@H]2CC(C(O3)=O)=C[C@H]3C/C(C)=C/1)CC4=CC=CC5=C4C=CC=C5
Molecular Formula
C27H24O6
Molecular Weight
444.48
References & Citations
[1]Feng JH, et al. A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice. Mol Cancer Ther. 2016 Jun;15 (6) :1163-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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