D-01

• Description :

  D-01 is a dual-targeting inhibitor of HIF-1α and EZH2 (IC50: 4.86 μM and 0.99 μM respectively) . D-01 inhibits the expression of H3K27me3 protein. D-01 inhibits the migration, clone and the invasion of A549 cells, and also inhibits tube formation of HUVECs. D-01 can be used for research of lung cancer[1].

• UNSPSC :

  12352005

• Target :

  HIF/HIF Prolyl-Hydroxylase; Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/d-01.html

• Smiles :

  CC1(C)OC2=CC=C(C(/C=C/C3=CC=C(OCCCN4CCOCC4)C(OCC(NCC5=C(C)C=C(C)NC5=O)=O)=C3)=O)C(O)=C2C=C1

• Molecular Formula :

  C37H43N3O8

• Molecular Weight :

  657.75

• References & Citations :

  [1]Xu H, et al. 2,2- dimethylbenzopyran derivatives containing pyridone structural fragments as selective dual-targeting inhibitors of HIF-1α and EZH2 for the treatment of lung cancer. Bioorg Chem. 2024 Jun;147:107419.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EZH2; HIF-1α