ACP1-01

• Description :

  ACP1-01 is a bacterial ClpP activator with EC50s of 3.4 and 2.6 μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP) . ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research[1][2].

• UNSPSC :

  12352100

• Target :

  Bacterial; ClpP

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  CC(C(NCCSC1=CC=CC=C1C(F)(F)F)=O)(S(=O)(C2=NC=C(C=C2)C(F)(F)F)=O)C

• Molecular Formula :

  C19H18F6N2O3S2

• Molecular Weight :

  500.48

• References & Citations :

  [1]Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126 (25) 00261-8. |[2]Mabanglo MF, et al. ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. Commun Biol. 2019 Nov 13;2:410.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1382489-31-7]