TH-Z145

• Description:

  TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM) [1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/th-z145.html

• Concentration:

  10mM

• Purity:

  99.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O

• Molecular Formula:

  C16H28O7P2

• Molecular Weight:

  394.34

• References & Citations:

  [1]Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175 (4) :1059-1073.e21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2260887-57-6]