TH-Z145

• Description :

  TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM) [1].

• CAS Number :

  [2260887-57-6]

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/th-z145.html

• Concentration :

  10mM

• Purity :

  99.69

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O

• Molecular Formula :

  C16H28O7P2

• Molecular Weight :

  394.34

• References & Citations :

  [1]Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175 (4) :1059-1073.e21.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported