TH-Z816

• Description :

  TH-Z816 is a reversible inhibitor againstKRAS (G12D) mutation with an IC50 value of 14 μM, which can be used in cancer research[1].

• UNSPSC :

  12352005

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/th-z816.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@H]1N(CCNC1)C2=C3C(CN(C4=CC=CC5=C4C(C)=CC=C5)CC3)=NC(OC[C@H]6N(CCC6)C)=N2

• Molecular Formula :

  C29H38N6O

• Molecular Weight :

  486.65

• References & Citations :

  [1]Zhongwei Mao, et al. KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8 (1) :5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2847881-42-7]