TH-263

• Description :

  TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  LIM Kinase (LIMK)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/th-263.html

• Purity :

  99.0

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C(NCC1=CC=CC=C1)C2=CC=C(S(=O)(NCC3=CC=CC=C3)=O)C=C2

• Molecular Formula :

  C21H20N2O3S

• Molecular Weight :

  380.46

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [313520-94-4]