TH-263

• Description:

  TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  LIM Kinase (LIMK)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/th-263.html

• Purity:

  99.0

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C (NCC1=CC=CC=C1) C2=CC=C (S (=O) (NCC3=CC=CC=C3) =O) C=C2

• Molecular Formula:

  C21H20N2O3S

• Molecular Weight:

  380.46

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  313520-94-4