TH-Z835

CAT: 0804-HY-146243-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-146243-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].

CAS Number

2766209-50-9

UNSPSC

12352005

Target

Apoptosis; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th-z835.html

Purity

99.59

Solubility

DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(CCC1)[C@@H]1COC2=NC(N3C[C@H]4N[C@H](CC4)C3)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2

Molecular Formula

C30H38N6O

Molecular Weight

498.66

References & Citations

[1]Mao Z, et al. KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8 (1) :5.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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GTR19219500-01	TH-Z835
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A24546-1	TH-Z835 1mg
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